Bone Abstracts

Objective: Classical homocystinuria due to cystathionine beta-synthase (CBS) deficiency, is a rare autosomal recessively inherited disease characterized by the multiple involvement on different organs. While the most striking cause of morbidity and mortality is thromboembolism, patients develop a marked osteoporosis at early age along with many other skeletal abnormalities. As CBS normally converts homocysteine to cystathionine, the result of CBS deficiency is an accumulation ...

Hydrogen sulfide (H2S) is a gaseous molecule produced endogenously in mammalian cells. H2S was recently found to play important roles in the regulation of inflammation, redox homeostasis and cell lifespan. Moreover, H2S was shown to maintain mesenchymal stem cell (MSC) function and stimulate osteogenic differentiation of MSC. However, it is unclear whether H2S plays any role in the bone loss induced by estrogen deficiency.<p clas...